This seven-day TSRC Summer School is organized by Arthur G. Palmer III of CoMD/NMR and Columbia University and John E. Straub of Boston University. The Summer School will be convened for the first time 24 to 31 July 2017. The Summer School will be followed, during the period 31 July to 4 August 2017, by the five-day Protein Dynamics workshop in which invited speakers who are experts in the field will present their latest research.
Theoretical and computational models of biomolecular systems are increasingly predictive, providing the opportunity to qualitatively interpret and quantitatively characterize the results of experiment. Nuclear Magnetic Resonance (NMR) spectroscopy has emerged as a major technique for the characterization of protein structure and dynamics, providing the opportunity in turn to benchmark and validate computational models. This Summer School will present state-of-the-art computational and experimental techniques for the study of biomolecular dynamics, emphasizing the synergy between theory, computation, and experiment. Students will develop an appreciation for the nature and scope of each technique. School Format
This summer school is designed for graduate students and postdoctoral fellows (with a preference for graduate students) from computational or experimental research groups who seek to develop an understanding of computation and NMR spectroscopy, including capabilities and limitations. Ten lectures will be delivered by leading experts in the field of computational and experimental studies of protein dynamics. Lectures will be paired with small-group problem-solving sessions, and discussions of current literature in which students will be challenged to apply the ideas presented.
The summer school will include a group project in which participants will be challenged to develop a research plan to address a fundamental question related to biomolecular dynamics using ideas developed in the school. The results of those group projects will be presented on the final day of the school at a mini-symposium attended by summer school participants and scientists attending the Protein Dynamics workshop. Social events and outdoor activities will allow students and lecturers to interact in an informal setting. Each student is expected to bring a laptop computer for use in problem solving exercises and group projects.
Martin Blackedge, Institut de Biologie Structurale, Grenoble, France
Teresa Head-Gordon, University of California, Berkeley
Ann McDermott, Columbia University, New York
Arthur G. Palmer III, University of Columbia Medical Center, New York
John E. Straub, Boston University, Boston
Instructors: Ann McDermott and Arthur Palmer Location: New York Structural Biology Center Times: 9:00 am -12:30 pm, June 14-16, 2016
This workshop will describe theoretical and practical approaches for characterizing conformational and kinetic processes of biological macromolecules in solution and solid states using NMR spectroscopy. The sessions will consist of lectures, tutorials, and problem solving. Workshop attendees should have a basic background in biological NMR spectroscopy.
Class size: 20 in-person (at NYSBC) and 20 remote (web-cast) attendees. Register by email to firstname.lastname@example.org. With subject line “NMR in motion registration” and indicate if you will attend in-person or remotely. Registration is on a first-come basis until capacity is reached. Syllabus
Theory Random-phase model for transverse relaxation BWR relaxation theory and the stochastic Liouville equation R1ρ in fast and slow regimes Solution techniques and data analysis CPMG and R1ρ pulse sequences and data analysis CEST pulse sequences and data analysis Solid-state R1ρ pulse sequences and data analysis