NMR determination of conformational landscapes. The atomic resolution provided by NMR spectroscopy allows detailed studies of conformational landscapes of biological macromolecules on ps-ns timescales using relaxation measurements (augmented by averaging of scalar and dipolar coupling constants, and other observables on slower timescales). TDP2 will use (i) computational, statistical and theoretical approaches for interpretation of NMR measurements, with an emphasis on linking NMR-derived information to other biophysical and structural methods; (ii) relaxation methods in solution and solid-state NMR spectroscopy that make optimal use of NMR spectrometers at multiple static magnetic fields, a strength of CoMD/NMR and NYSBC; and (iii) software to facilitate planning and analysis of these experiments.