Application of advanced instrumentation for new probes of dynamics: Complex biological dynamics are generally underdetermined by available experimental information. Consequently, new methods providing additional restraints can be transformative. CoMD/NMR has access at NYSBC to advanced hardware, including a field-cycling shuttle system for relaxometry, static and dynamic (jump) pressure apparatus, rapid-freeze quench (RFQ) apparatus, and dynamic nuclear polarization (DNP). To make these technologies available to the broader research community, TDP3 (i) implements broadly applicable experimental methods using these hardware resources (ii) applies data analysis protocols for improved accuracy and precision of experimental results, and (iii) develops appropriate experimental protocols.