Center on Macromolecular Dynamics by NMR Spectroscopy

The Center on Macromolecular Dynamics by NMR Spectroscopy (CoMD/NMR) is a Biomedical Technology Research Resource (BTRR) supported by U.S. National Institutes of Health grant P41 GM118302 and located at the New York Structural Biology Center (NYSBC). The mission of CoMD/NMR is to make available to the biological research community advanced NMR spectroscopic and computational methods for characterizing protein and nucleic acid conformational dynamics in biological processes.

Staff Technology Collaboration Education Dissemination

News and Events

CoMD/NMR is launched!

CoMD/NMR begins on June 1, 2017


New educational materials available: Tutorial on Model-free analysis of 15N relaxation data.


NMR Spectroscopy of Macromolecules to be taught at NYSBC, Spring 2020.

Recent Publications

Cadherin-11 dimerization multi-site kinetics: combined partial unfolding and strand-swapping.
Koss, H., B. Honig, L. Shapiro, *A. G. Palmer. Structure. (2021) in press.

Bootstrap aggregation for model selection in the model-free formalism
Crawley, T., *A. G. Palmer. Magn. Reson. (2021) 2:251-264.

Approximate representations of shaped pulses using the homotopy analysis method
Crawley, T., *A. G. Palmer. Magn. Reson. (2021) 2:175-186.

RING NMR dynamics: software for analysis of multiple NMR relaxation experiments.
Beckwith MA, Erazo-Colon T, Johnson BA Journal of biomolecular NMR 75 9-23 2021 Jan

Informing NMR experiments with molecular dynamics simulations to characterize the dominant activated state of the KcsA ion channel.
Pérez-Conesa S, Keeler EG, Zhang D, Delemotte L, McDermott AE The Journal of chemical physics 154 165102 2021 Apr 28

Asterix/Gtsf1 links tRNAs and piRNA silencing of retrotransposons.
Ipsaro JJ, O'Brien PA, Bhattacharya S, Palmer AG 3rd, Joshua-Tor L Cell reports 34 108914 2021 Mar 30

Algebraic expressions for Carr-Purcell-Meiboom-Gill relaxation dispersion for N-site chemical exchange.
Koss H, Rance M, Palmer AG 3rd Journal of magnetic resonance (San Diego, Calif. : 1997) 321 106846 2020 Dec

Quantifying the Relationship between Conformational Dynamics and Enzymatic Activity in Ribonuclease HI Homologues.
Martin JA, Robustelli P, Palmer AG 3rd Biochemistry 59 3201-3205 2020 Sep 8

Compact expressions for R1ρ relaxation for N-site chemical exchange using Schur decomposition.
Rance M, Palmer AG 3rd Journal of magnetic resonance (San Diego, Calif. : 1997) 313 106705 2020 Apr

Scaled recoupling of chemical shift anisotropies at high magnetic fields under MAS with interspersed C-elements.
Fritzsching KJ, Keeler EG, He C, McDermott AE The Journal of chemical physics 153 104201 2020 Sep 14

Probing allosteric coupling in a constitutively open mutant of the ion channel KcsA using solid-state NMR.
Sun Z, Xu Y, Zhang D, McDermott AE Proceedings of the National Academy of Sciences of the United States of America 117 7171-7175 2020 Mar 31

Collagen I Weakly Interacts with the β-Sheets of β2-Microglobulin and Enhances Conformational Exchange To Induce Amyloid Formation.
Hoop CL, Zhu J, Bhattacharya S, Tobita CA, Radford SE, Baum J Journal of the American Chemical Society 142 1321-1331 2020 Jan 22

All CoMD/NMR publications at PubMed